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Recommended Series | α-L-Fucosidase Substrate: The Science and Technology Behind Precision Medicine
2025/1/13 11:34:49 Browse volume(45)In daily life, smart door locks ensure home security through rapid fingerprint recognition. Similarly, within the human body, α-L-fucosidase (AFU) acts as a silent guardian, not only participating in normal physiological processes but also playing a crucial role in disease diagnosis. Let's explore this special enzyme and its substrates to understand their importance in maintaining health.
α-L-fucosidase (AFU) is a lysosomal acid hydrolase widely found in various tissues, blood, and bodily fluids of the human body. Its primary function is to catalyze the hydrolysis of large molecules such as glycoproteins and glycolipids containing fucose residues, thus participating in complex metabolic processes.
AFU not only plays an essential role under normal physiological conditions but also exhibits unique diagnostic value in various diseases. Particularly noteworthy is its role in the early screening and diagnosis of liver cancer. Studies have shown that AFU has a sensitivity and specificity of 75% and 90%, respectively, in diagnosing liver cancer, higher than traditional tumor markers like alpha-fetoprotein (AFP). Moreover, combined detection of AFU and AFP can increase the sensitivity of diagnosing primary liver cancer to 91.30%, with an accuracy rate reaching 91.04%, significantly reducing the likelihood of missed diagnoses and enhancing diagnostic precision and comprehensiveness.
2. Importance of Enzyme Substrates and Detection Principles
α-L-fucosidase operates like a specialized task force dealing with L-fucose-containing complex molecules in the body. These molecules are akin to encrypted information that can only be unlocked and decomposed by specific keys—enzyme substrates. The choice of substrate is critical for ensuring accurate detection results. An ideal substrate should possess high specificity, rapid reaction, stability, and ease of use. To this end, Geneseqtools Biotechnology has developed multiple AFU substrates, including 2-chloro-4-nitrophenyl-α-L-fucopyranoside (CNP-AFU) and 4-nitrophenyl-α-L-fucopyranoside (PNP-α-L-Fucoside). These substrates undergo specific hydrolysis reactions with AFU, producing easily detectable products.
Detection Principle: 2-Chloro-4-nitrophenyl-α-L-fucopyranoside (CNP-AFU) is hydrolyzed by α-L-fucosidase in the sample to produce 2-chloro-4-nitrophenol (CNP). Measuring the increase in absorbance of CNP allows for determining AFU activity.
Just as specific molecular probes need to precisely bind to target proteins, high-quality AFU substrates are indispensable for achieving precision medicine. Choosing the right substrate is akin to finding the most compatible molecular partner for fucosidase, making each test more accurate and reliable. Below are some AFU substrate series products independently developed and produced by Geneseqtools Biotechnology:
CAS Number： 157843-41-9
Chinese Name： 2-氯-4-硝基苯-α-L-巖藻糖苷
Another Name： CNP-α-L-Fucoside
Product Packaging：mg to g level
Application： Enzyme Substrate
Product Code： G01060012
CAS Number： 10231-84-2
Chinese Name： 4-硝基苯基-α-L-吡喃巖藻糖苷
Another Name： PNP-α-L-Fucoside
Product Packaging：mg to g level
Application： Enzyme Substrate
Product Code： G01060011
CAS Number： 171869-92-4
Chinese Name： 5-溴-4-氯-3-吲哚-α-L-吡喃巖藻糖苷
Another Name： X-α-L-Fucoside
Product Packaging：mg to g level
Application： Enzyme Substrate
Product Code： G01010017
CAS Number： 1222705-28-3
Chinese Name： 5-溴-6-氯-3-吲哚-α-L-吡喃巖藻糖苷
Another Name： Magenta-α-L-Fucoside
Product Packaging：mg to g level
Application： Enzyme Substrate
Product Code： G01020012
CAS Number： 54322-38-2
Chinese Name： 4-甲基傘形酮基-α-L-巖藻糖苷
Another Name： 4MU-α-L-Fucoside
Product Packaging：mg to g level
Application： Enzyme Substrate
Product Code： G01070022
CAS Number： 63503-05-9
Chinese Name： 2-萘基-α-L-巖藻糖
Another Name： 2-Naphthyl-α-L-Fucoside
Product Packaging：mg to g level
Application： Enzyme Substrate
Product Code： G01080021
For more product information, please visit the Geneseqtools website: http://www.dg99.com.cn
Founded in 2015, the company focuses on the research, development, production, and sales of biochemical reagents for microbial detection, gene sequencing, and in vitro molecular diagnostics. We are committed to providing high-quality biochemical reagents and professional custom synthesis services. Our product range covers over a dozen categories with nearly a thousand innovative products. Adhering to the core values of "Customer First, Integrity, and Professionalism," we strive to meet the diverse needs of our clients in research and testing.
WeChat Office Account：Geneseqtools Biotech
Geneseqtools Website：http://www.dg99.com.cn
Consultation Hotline：+86-0755-36820717
QQ：2370561481
Email：sales@geneseqtools.com
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